DES-GAMMA CARBOXY PROTHROMBIN (DCP)/PIVKA II, SERUM Test in Chennai

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    Test Recommended For:

    Male

  • Report Frequency :

    Daily

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  • parameter icon

    Parameters :

    1

Special Instruction :
Give brief clinical history.

Overview

PIVKA II is a marker for the commonest type of liver cancer called Hepatocellular carcinoma (HCC). This test is used as a screening tool in patients of chronic liver disease who are at risk of developing liver cancer. HCC affects more men than women & average age at the time of diagnosis is 62 years.

Parameters

Doctor Information

Code

Pre-test Information

Give brief clinical history.

Code

Report Delivery

Daily

Code

Code

F026

Category

Category

Cancer

Stability Room

Stability Room

8 hrs

Stability Refrigerated

Stability Refrigerated

1 week

Stability Frozen

Stability Frozen

6 weeks

Method

Method

CMIA

Specimen

Usage

Des-gamma carboxyprothrombin (DCP) also known as PIVKA II (Prothrombin induced by Vitamin K antagonist II) is an abnormal prothrombin that is increased in the sera of patients with Hepatocellular Carcinoma (HCC). Unlike AFP, it is not elevated in Chronic Liver Disease, Cirrhosis, pregnancy or Germ Cell Tumors. It is a complementary biomarker to AFP in HCC and increases the sensitivity (83%) and specificity (84%) for HCC when used in combination. It is recommended to measure two or more different tumor markers (AFP, DCP or AFP L3) for the diagnosis of HCC at an early stage. Moreover, DCP has been found to correlate better with tumor size, histological grade, portal vein invasion and/or intrahepatic metastasis in patients with HCC.

Specimen

Specimen

2 mL (0.5 mL min.) Serum from 1 SST. Ship refrigerated or frozen. Give brief clinical history.

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