Menopause is permanent cessation of menstruation due to loss of ovarian follicular function. Accurate estimation of the time of menopause could improve the preventive management of women's health. Reproductive hormones reflect the activity of follicle pools and provide information about ovarian aging. Ovarian mass and fertility decline sharply after 35 years of age and specially during perimenopause which is characterized by accelerated follicular phase and shortening of intermenstrual intervals. Transition from perimenopause to menopause may take 2-8 years with an average of 4 years. During perimenopause hormone levels are irregularly irregular but after menopause FSH levels rise and estradiol levels decrease. Thyroid disorders can lead to menstrual irregularities which can be easily excluded by measuring TSH levels. Serum AMH levels become low approximately five years before the final menstrual period and are undetectable in postmenopausal women.