MICROSATELLITE INSTABILITY (MSI), PCR

The presence of MSI is a sign of DNA mismatch repair deficiency that can be inherited, caused by gem line mutation in MSH2 gene or sporadic due to hypermethylation of MLH1 promoter. Microsatellite instability (MSI)-High indicates a tumor with instability in two or more microsatellite repeats. MSI-High occurs in approximately 90% of colorectal cancers from individuals with Lynch syndrome.

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  • Pre-test Information:
  • Report Delivery:
    Sample by Mon 11 am; Report Sat
  • Components:
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