LAD is an autosomal recessive immunodeficiency disorder that affects the leucocyte adhesion process and is associated with recurrent bacterial and fungal infections. Two forms of LAD have been described. LAD-I is associated with defective expression of CD18 by neutrophils resulting from mutations in the integrin beta-2 gene (ITGB2), encoding CD18 of beta-2 integrins. LAD-II is associated with defective expression of CD15s (sialyl-Lewis X) resulting from mutations in the Glucose diphosphate (GDP)-fucose transporter gene. Genetic testing for the ITGB2 gene (associated with LAD-I) is recommended to verify specific mutation and confirm diagnosis while preparing for Hematopoietic Cell Transplantation (HCT).