IMMUNOHISTOCHEMISTRY, CALDESMON

Caldesmon is a smooth muscle and nonmuscle regulatory protein that interacts with actin, myosin, tropomyosin, and calmodulin. Smooth muscle caldesmon is an elongated molecule with a calmodulin, tropomyosin, and action-binding region at the C-terminus and a myosin binding domain at the N-terminus. Caldesmon stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, caldesmon inhibits the actomyosin ATPase by binding to F-Actin. Caldesmon is a useful marker for smooth muscle tumors.

  • Test Type:
  • Pre-test Information:
    Provide a copy of the Histopathology / Cytopathology report & give brief clinical history.
  • Report Delivery:
    Sample daily by 6 pm Report Blocks : 5 Days Tissues : 7 Days
  • Components:
    0

Sample Report