Human herpesvirus 6 (HHV6), a beta herpes virus, has linear, double-stranded DNA molecule. This virus shows the closest homology with Cytomegalovirus and Human herpes virus 7 (HHV7). The virus is spread through saliva and possibly by genital secretions. HHV6 infection in infants results in Exanthema subitum (Roseola) and is the most common cause of fever-induced seizures. Roseola is estimated to affect as many as 30% of all children and is most common in spring and fall. Infection in adults is seen primarily in immunocompromised hosts who have undergone organ transplants or in those with HIV infection.