HLA HYPERSENSITIVITY TO ALLOPURINOL (B*58;01)

Presence of HLA B*58:01 is associated with hypersensitivity to Allopurinol therapy. Allopurinol is widely used for hyperuricemia related diseases such as Gout, Lesch- Nyhan Syndrome and recurrent urate kidney stones. Such individuals are at risk of developing Allopurinol hypersensitivity syndrome which includes Toxic Epidermal Necrolysis (TEN) or Stevens- Johnson Syndrome (SJS) and also features of eosinophilia, vasculitis and major end organ disease. Patients of Han Chinese or Thai descent are at a very high risk for developing Allopurinol hypersensitivity syndrome. Therapy should be discontinued immediately and permanently if Allopurinol hypersensitivity syndrome develops.

  • Test Type:
  • Pre-test Information:
    No Special preparation required
  • Report Delivery:
    Sample Daily by 9 a.m; Report 7 days.
  • Components:
    0

Sample Report