FISH-MYCN AMPLIFICATION

The MYCN gene, which encodes the n-myc protein, is a proto-oncogene with highest expression in the developing brain and insignificant expression in normal adult tissues. Gene amplification is detected in approximately 20% of Neuroblastoma and a variety of other solid tumors including 5% Medulloblastoma, Glioblastoma multiforme, 25% Alveolar rhabdomyosarcoma, 15-20% Small-cell lung cancer, 40% Neuroendocrine prostate cancer, and 5% Prostate adenocarcinoma. MYCN amplifications are associated with aggressive disease and/or poor outcome. Detection can be useful to stratify patients for aggressive treatment.

  • Test Type:
  • Pre-test Information:
    Clinical history mandatory.
  • Report Delivery:
    Sample Daily by 4 pm; Report 7 days
  • Components:
    0

Sample Report