Chromosome analysis helps in the diagnosis of a wide variety of congenital conditions. It helps in the identification of congenital chromosome abnormalities like Aneuploidy (Trisomy / Monosomy) & structural chromosome abnormalities. Lupus Anticoagulants are heterogenous IgG or IgM autoantibodies which interfere with phospholipid dependent in vitro coagulation tests, particularly Activated Partial Thromboplastin Time (APTT). These antibodies are associated with thrombosis (arterial & venous), recurrent abortions, neurological & neuropsychiatric disorders. Cardiolipin antibodies are useful in identifying patients with an increased risk of thrombosis, recurrent spontaneous abortions and phospholipid antibody syndrome. Anti Beta 2 Glycoprotein 1 (Beta 2GP1) antibodies are independent risk factor for thrombosis in autoimmune diseases and complications of pregnancy.