5 FLUOROURACIL TOXICITY (DPD GENE MUTATION)

Fluorouracil (5-FU) is a commonly used anticancer drug. It functions by irreversibly inhibiting thymidylate synthase. 5-FU is widely used in a number of cancers worldwide. Detoxification of 5-FU is mediated by the dihydropyrimidine dehydrogenase (DPD) gene . Apart from 5-FU, the gene also is involved in detoxification of Capecitabine, and Tegafur. Genetic variations in the gene can cause a partial or complete deficiency of function, which may lead to drug toxicity, which is severe.

  • Test Type:
  • Pre-test Information:
    It is mandatory to send a Signed Genomics Clinical information form (Form 20) with the specimen.
  • Report Delivery:
    Sample by Mon 11 am; report Friday
  • Components:
    0