Dr. Anand Chandrasekaran Annan

Head Oncopathology,

National Reference Laboratory

Dr Lal PathLabs Ltd

Qualification:

  • MD (Diplomate of the American Board of Pathology in Anatomic and Clinical Pathology)
  • PhD (Molecular and Cellular Pathology, USA)
  • MBBS (Kilpauk Medical College, Chennai, India)

Expertise:

  • Hematopathology (including lymph node pathology)
  • Oncopathology
  • Multicolor Flow cytometry
  • Molecular Oncopathology

Key Credentials:

  • Fellowship in Hematopathology at Cleveland Clinic, Ohio, USA
  • Fellowship in Surgical Pathology at Emory University, Georgia, USA

Area of Interest:

  • Myeloid neoplasms
  • Cancer Genetics
  • Precision Medicine

Research & Publications:

  • Annan AC, Stevens KA, Osunkoya AO. Urothelial carcinoma involving the ureteral orifice: a clinicopathologic analysis of 93 cases. Human Pathology (2017); Epub ahead of print. [PMID: 28465130]
  • Annan AC, Fisher PB, Dent P, Siegal GP, Curiel DT. Gene Therapy in the Treatment of Human Cancer. (Book chapter) The Molecular Basis of Human Cancer, 2nd edition, 2017 edition, Editors: William B. Coleman and Gregory J. Tsongalis, Humana Press: Page number 811-842. [ISBN-13: 978-1934115183; ISBN-10: 1934115185]
  • Jeffries MA, Donica M, Baker L, Stevenson M, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant novel intraarticular epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage. Arthritis Rheumatology (2016); 68(6) 1403-14. [PMID: 26713865]
  • Buggio M, Towe C, Annan A, Kaliberov S, Lu ZH, Stephens C, Arbeit JM, Curiel DT. Pulmonary vasculature directed adenovirus increases epithelial lining fluid Alpha-1 Antitrypsin levels. J Gene Medicine (2016); 18(1-3) 38-44. [PMID: 26825735]
  • Jeffries MA, Donica M, Baker L, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant novel intraarticular epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatology (2014); 66(10) 2804-15. [PMID: 24980887]

Oral Presentation:

  • “Gastrointestinal Pathology – Review for Gastroenterology and Hepatology Boards” for clinical Gastroenterology fellows, May 2016, Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
  • “Development of a Strategy to Knock-Down SDF-1 as a means to Prevent Pulmonary Metastasis”, at Breast Cancer Research Roundtable, Susan G. Komen for the Cure, North Central Alabama Affiliate, August 25, 2010, Birmingham, AL, USA

Abstracts and Poster Presentations:

  • Annan AC, Durkin L, Xie Y, His E. PD-L1 Expression in Nodular Lymphocyte predominant Hodgkin Lymphoma (NLPHL) and Its Immunoarchitectural Variants. Modern Pathology. 2018 31(S2): 496 (USCAP 2018, Vancouver, Canada)
  • Annan AC, Siddiqui MT, Bhimji-Pattni S, Cohen C. PD-L1 Expression in Male Breast Carcinoma and Its Correlation with Patient Demographics, Histologic Grade and Prognostic/Predictive Markers. Modern Pathology. 2017 30(S2): 29A (USCAP 2017, San Antonio, USA)
  • Ormenisan Gherasim C, Annan AC, Bilir B, Moreno CS, Osunkoya AO. SOX4 Expression in Prostatic Adenocarcinoma with Matched Lymph Node Metastasis. Modern Pathology. 2017 30(S2): 247A (USCAP 2017, San Antonio, USA)
  • Annan AC, Siddiqui MT, Bhimji-Pattni S, Cohen C. PD-L1 Expression in Male Breast Carcinoma: Comparison of RNA In Situ Hybridization Technology vs Immunohistochemistry. Modern Pathology. 2017 30(S2): 525A (USCAP 2017, San Antonio, USA)
  • Annan AC, Zhao JZ, Smith K, Husain S, Gillies E, Zuna R. Ambiguous p53 Immunohistochemical Patterns and Role of Tissue Processing: Correlation with DNA Sequencing. Modern Pathology. 2016 29(S2): 489A (USCAP 2016, Seattle, USA)
  • Annan AC, Scordino T. Panel discussion on “HHV8- associated Castleman disease in an immune-deficient patient”. Society for Hematopathology/European Association for Haematopathology workshop, Oct 2015, Long Beach, CA
  • Te JC, Salvaggio M, Higuita NA, McCloskey C, Murray C, Annan AC. Fungal Endocarditis with C. parapsilosis and Ensuing Complications
  • Husain S, Zhao J, Annan AC, Tran H, Zuna RE. Clinicopathologic characteristics of endometrial carcinomas with POLE mutations. Mod Pathology 2015 Feb; 28(S2):290A; doi:10.1038/modpathol.2015.17. (Abstract 1159, USCAP 2015, Boston, USA)
  • Annan AC, Li S, Kraus TS, Kim YM, Lu X, Ruiz-Elizalde A, Yu, Z. Diffuse Large B-Cell Lymphoma With Complex Karyotype and t(13;14) Involving FOXO1 Gene: A Case Report on a Novel Translocation. (2014) Abstracts and Case Studies From the College of American Pathologists 2014 Annual Meeting (CAP `14). Archives of Pathology and Laboratory Medicine: September 2014 138(9): pp. e2-e183
  • Annan AC, Lindley SW, Yeh MM, Jayaprakash V, Fung KM. AKR1C3 as a marker to distinguish well-differentiated HCC from benign hepatic lesions. Modern Pathology. 2014 27(S2): 417A (USCAP 2014, San Diego, USA)
  • Annan AC, Lindley SW, Hassell LA. Periampullary Adenomyoma With Lipomatous Elements: Two Cases Mimicking Carcinoma. Archives of Pathology and Laboratory Medicine. 2013 137: 1404 (CAP 2013, Orlando, USA)
  • Annan AC, McCloskey CB, Rabb CH, Fung KM. Brain Abscess associated with Mycobacterium kansasii and Mycobacterium lentiflavum in a HIV patient. Archives of Pathology and Laboratory Medicine. 2013 137: 1387 (CAP 2013, Orlando, USA)
  • Jeffries MA, Donica M, Baker L, Stevenson M, Annan AC, Humphrey MB, James J, Sawalha A. Epigenome-wide DNA methylation study reveals hypermethylated collagen genes and suggests a role for epigenetic dysregulation of TGF-beta in osteoarthritis. (Poster presented in American Society of Human Genetics, Annual meeting, Boston, 2013; Poster presented in American College of Rheumatology, Annual meeting, San Diego, 2013; Oral presentation in Oklahoma Skeletal Biology Symposium, Oklahoma City, 2013)
  • Annan AC, Preuss MA, Borovjagin AV, Ugai H, Curiel DT. Development of a strategy to knock down SDF-1 using shRNA as a means to prevent pulmonary metastasis. American Association for Cancer Research (AACR), 101st Annual meeting held in Washington DC, 2010
  • Annan AC, Borovjagin AV, Ugai H, Curiel DT. In situ inhibition of SDF-1/CXCR4 axis mediated by the knock-down of SDF-1 prevents pulmonary metastasis. The American Society of Gene & Cell Therapy (previously The American Society of Gene Therapy), 11th Annual meeting held at Boston, MA 2008

Honors and Awards:

  • William P. Illig Award for Outstanding Pathology Resident Research, 2016, Department of Pathology, University of Oklahoma Health Sciences Center
  • Parker-Heartland Award for Excellence in Pathology Graduate Medical Education (for outstanding performance in anatomic pathology), 2015, Department of Pathology, University of Oklahoma Health Sciences Center
  • Travel Award from “Susan G. Komen for the Cure, North Central Alabama Affiliate” for 2010
  • Travel Award from “Susan G. Komen for the Cure, North Central Alabama Affiliate” for 2008
  • Travel Award from “Graduate Student Association at University of Alabama at Birmingham” for 2008