· Unusual Variants Of Diffuse Large B - Cell Lymphoma At Extranodal Sites. - Are These Distinct Diagnostic Entities. Hema Malini Aiyer. World Journal of Surgical Medical and Radiation Oncology Volume No 7. Nov 2013

Context Diffuse Large B - Cell Lymphoma (DLBCL) is a heterogeneous category of Mature B- Cell Neoplasms in the updated 2008 WHO Classification. We Present here the more uncommon variants in unusual locations that have unique Clinicopathologic features and which the author believes are possibly distinct biologic entities in our experience.ObjectiveWe highlight here the clinicopathologic and immunohistochemical features of a few of the more uncommon variants and also discuss actual scenarios and practical difficulties encountered in cases presenting to our institution Data sources Material from the author's institution, CAP Protocol for the examination of specimens from patients with Non Hodgkin's Lymphoma / Lymphoid neoplasms, literature from PubMed and the WHO Classification of tumors of hematopoietic and lymphoid tissues 2008.Conclusions While WHO recognizes several morphologic and clinical subtypes of DLBCL, their distinction and categorization and site specific features remain difficult to reproduce, lack of consensus among reporting pathologists further hampering accurate delineation. Many variants moreover, clubbed under the rubric of DLBCL NOS probably are distinct biologic entities, which need to be recognized as such. Key words diffuse large B-cell lymphoma; Extranodal sites; Distinct Diagnostic Entities

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