Gold Standard Technology Introduced for Diagnosing Vitamin D
Dr Lal PathLabs Introduces Gold Standard Technology for Diagnosing Vitamin D Levels: Vitamin D Ultrasensitive test (Vitamin D by LCMS/MS) by Tandem Mass Spectrometry.
Why it is Gold standard?
• Correct identification of 25(0H)D3 & 25(OH)D2 for proper treatment
• Capability to overcome problems associated with protein binding assays
• Internal standard usually compensates for any matrix related and instrumental defects
Advantages:
Dr Lal PathLabs offers Vitamin D Ultrasensitive test (Vitamin D by LCMS/MS) with advantages over other leading laboratories-
DR LAL PATHLABS LTD. | OTHER LEADING TESTING LABORATORY |
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LC-MS/MS test can: •Accurately identify and quantitate 25(OH)D3 & D2 •Chromatographically separate Epi 25(OH)D3 & Epi 25(OH)D2 •No Missed Deficiency Diagnosis |
•Epimers are not quantified •Total vitamin 25(OH)D may be inflated to appear as normal •Diagnosis of deficiency can be missed |
FACT FILE
A) Proper measurement of total Vitamin 25(OH)D:
- Technique should detect both 25(OH)D2 & D3
- Total should represent the total circulating amount of both Vitamin D2 & D3
B) Sub-standard Immunoassay Technology:
Present commonly used technology has 3 drawbacks:
- Total circulating Vitamin 25(OH)D and equivalent detection of both 25(OH)D2 & D3 not possible
- Binding protein shows a higher affinity for 25(OH)D3 than 25(OH)D2 hence these assays can measure only D3
- Immunoassay for 25(OH)D have been reported to cross-react with 24, 25(OH)2 D3-an intermediate product during the formation of 1,25(OH)2D3 in the kidney
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