Aug 31, 2017
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Gold Standard Technology Introduced for Diagnosing Vitamin D

 

LFT 2

Dr Lal PathLabs Introduces Gold Standard Technology for Diagnosing Vitamin D Levels: Vitamin D Ultrasensitive test (Vitamin D by LCMS/MS) by Tandem Mass Spectrometry.

Why it is Gold standard?

• Correct identification of 25(0H)D3 & 25(OH)D2 for proper treatment
• Capability to overcome problems associated with protein binding assays
• Internal standard usually compensates for any matrix related and instrumental defects

Advantages:

Dr Lal PathLabs offers Vitamin D Ultrasensitive test (Vitamin D by LCMS/MS) with advantages over other leading laboratories-

DR LAL PATHLABS LTD. OTHER LEADING TESTING LABORATORY
LC-MS/MS test can:
•Accurately identify and quantitate 25(OH)D3 & D2
•Chromatographically separate Epi 25(OH)D3 & Epi 25(OH)D2
•No Missed Deficiency Diagnosis
•Epimers are not quantified
•Total vitamin 25(OH)D may be inflated to appear as normal
•Diagnosis of deficiency can be missed

FACT FILE

A) Proper measurement of total Vitamin 25(OH)D:

  • Technique should detect both 25(OH)D2 & D3
  • Total should represent the total circulating amount of both Vitamin D2 & D3

B) Sub-standard Immunoassay Technology:
Present commonly used technology has 3 drawbacks:

  • Total circulating Vitamin 25(OH)D and equivalent detection of both 25(OH)D2 & D3 not possible
  • Binding protein shows a higher affinity for 25(OH)D3 than 25(OH)D2 hence these assays can measure only D3
  • Immunoassay for 25(OH)D have been reported to cross-react with 24, 25(OH)2 D3-an intermediate product during the formation of 1,25(OH)2D3 in the kidney

Gold Standard Technology Introduced for Diagnosing Vitamin D was last modified: by

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